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LEAP / Challenge Buckets

You can submit solutions to more than one Challenge.

LEAP 2.0- advisory for participating students

1. Accessibility and affordability of immunotherapy in oncology care

The accessibility and affordability of immunotherapy in oncology care are critical factors that impact the availability of this advanced treatment to cancer patients. Immunotherapy has shown significant promise in the treatment of various cancers, but its cost and availability can be challenging for many patients. What are the potential solutions to enhance accessibility and affordability?

You are required to:

  • Identify global patient access programs from other therapies (optional) that can serve as an example in oncology.

  • Develop a path on how pharmaceutical companies work with healthcare providers and governments to find solutions for reducing the cost of

  • immunotherapy and improving patient access.

    Look at what advocacy efforts can help push for legislative changes that improve access to affordable immunotherapy for cancer patients.

2. How can we effectively integrate emerging immunotherapies and targeted therapies into existing treatment protocols to improve patient outcomes?

Effectively integrating emerging immunotherapies and targeted therapies into existing treatment protocols is crucial for enhancing patient outcomes in oncology. This integration aims to leverage the strengths of both approaches, potentially leading to more effective and personalized cancer treatments.

You are required to:

1. Identify effectiveness of immunotherapies and targeted therapies, their advantages and challenges in using them in the clinic

2. Identify biomarkers that help in therapy decision making

3. List challenges in utilization of Immunotherapy and targeted therapies in all patients

4. Find possible solutions for these challenges

3. Impact of steroids on cancer immunotherapy

Steroids can have a significant impact on cancer immunotherapy, as they can modulate the immune response and potentially affect the effectiveness of immunotherapeutic treatments. The use of steroids in cancer patients receiving immunotherapy is a complex issue, and its impact can vary depending on several factors, including the type of immunotherapy, the timing of steroid administration, and the patient's circumstances. What are some of the key considerations regarding the impact of steroids on cancer immunotherapy?

You are required to:

  • Elaborate on the optimal timing of steroid administration.

  • Develop approaches that can help balance the potential benefits of managing side effects with the potential reduction in immunotherapy efficacy.

  • Develop solutions on individualizing steroid administration in cancer care.

4. Navigating Immunotherapy Resistance in Oncology

Navigating immunotherapy resistance in oncology involves understanding the mechanisms that prevent effective immune responses against tumors, which can significantly hinder treatment outcomes. The resistance can necessitate tailored strategies to enhance the efficacy of immunotherapeutic approaches.

You are required to:

1. Identify current landscape of Immuotherapy and resistance mechanims

2. Identify combination therapies that are showing to overcome resistance to Immunotherapy

3. What are the current knowledge gaps in resistance mechanism to Immunotherapy

4. Prepare a list of possible ways to predict and overcome resistance to immunotherapy


Submission of solutions/entries deadline till June 15, 2025

Disclaimer: This is an educational and knowledge initiative. Roche Products (India) Private Limited reserves its rights to change or cancel any of the requirements of the program or stop the program entirely at any time. All rights reserved Roche Products (India) Private Limited.